neuroprotective effect of coenzyme q10 in hippocampal injury in balb/c mouse

coenzyme q10 is a promising   agent for neuroprotection in neurodegenerative   diseases. neuroprotective effects of coenzyme q10 demonstrated in some   neurodegenerative diseases such as parkinson, alzheimer and etc. hippocampus   is home of these diseases. we assayed coenzyme q10 effects on hippocampal   injury model and our hypothesis is that coenzyme q10 has neuroprotective   effects in some   neurodegenerative diseases via hippocampus. for this purpose 24 balb/c mouse   took in 4 groups: control (without any treatment), vehicle (treated with   sesame oil as coenzyme q10 vehicle), hyppocampal injury model (treated with trimethyltin   chlorideneurotoxin, 2.5 mg per kg ip), and test (treated with coenzyme q10   after trimethyltin chloride injection, 10 mg per kg ip for 2 weeks). after two   weeks brain harvested and hippocampus tissue assayed by nissl and tunnel   staining. hystological study showed significantly increase of normal cells   and decrease of apoptotic cells in test group after coenzyme q10 treatment in   hippocampus. this study showed coenzyme q10 has protective effects in   hippocampus after injury and it seems that neuroprotective effects of coenzyme   q10 in some neurodegenerative diseases com from that.